Genetic Epidemiology Of Plasma Homocysteine Levels.pdf

Genetic Epidemiology Of Plasma Homocysteine Levels

Ioana Cotlarciuc

Elevated plasma homocysteine levels represent a risk factor for many complex diseases, including cardiovascular disease. Plasma homocysteine, a sulphur containing amino-acid, is a quantitative trait with a complex architecture, affected by multiple genetic and environmental factors. Using the classical twin model, plasma homocysteine levels showed to be highly heritable with a heritability estimate of 48%, warranting efforts in identifying genetic variants associated with this complex trait. A large meta-analysis of ten GWAS on plasma homocysteine levels with a total sample of 44,147 individuals has identified 13 genetic loci associated with plasma homocysteine levels, of which six were novel, located at or near HNF1A, CUBN, MMACHC, FUT2, SLC17A3, GTPBP10, while the rest of seven loci were previously known associations located at or near MTHFR, DPEP1, CBS, NOX4, CPS1, MTR and MUT gene. These findings provide novel insights into the genetic architecture of plasma homocysteine contributing to improving the understanding of the biological mechanisms underlying plasma homocysteine variation.

Homocysteine | definition of homocysteine by …

9.67 MB DATEIGRÖSSE
3659284041 ISBN
Englisch SPRACHE
Genetic Epidemiology Of Plasma Homocysteine Levels.pdf

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Sofia Voigt

Therefore plasma homocysteine levels are determined by several factors, such as the cofactors vitamin B12, vitamin B6 and folic acid and enzymes involved in methionine metabolism. Their levels are inversely correlated, with plasma homocysteine levels increasing as vitamin B concentrations decrease (2).

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Genetic Epidemiology of Plasma Homocysteine … Compre o livro Genetic Epidemiology of Plasma Homocysteine Levels na Amazon.com.br: confira as ofertas para livros em inglês e importados

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Genetic Epidemiology Of Plasma Homocysteine Levels: Cotlarciuc, Ioana: 9783659284045: Books - Amazon.ca. Skip to main content. Try Prime EN Hello, Sign in Account & Lists Sign in Account & Lists Returns & Orders Try Prime Cart. Books. Go Genetic Epidemiology Of Plasma Homocysteine Levels - Ioana ...

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Jason Lehmann

Background Elevated plasma total homocysteine (tHcy) predisposes to vascular disease and results from interactions between genetic and nutritional factors. MTHFR C677T ... The prevalence of MTHFR C677T was CC 42%,. CT 48%,TT 10%; ...

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Jessica Kohmann

Genetic Association of Plasma Homocysteine …