Antiarrhythmic Drugs
W. HaverkampThe past 10 years have seen a remarkable change in the approach to cardiac arrhythmias, from a position of confidence and a feeling of well-being about pharmacological treatment to a situation in which there is now marked uncertainty and general apprehension about the role of antiarrhythmic drugs. Until relatively recently the prevailing concept in antiarrhythmic therapy was that arrhythmias could be controlled by drugs which slowed conduction or suppressed automaticity, goals well served by the sodium channel-blocking drugs and glycosides. Drug re search was based largely on the development of agents mimicking those already available, but with greater efficacy, fewer side effects or a more favourable phar macokinetic profile. The CAST trial stands out as a landmark in the evolution of arrhytmia manage ment
The major antiarrhythmic drugs (those in Class I and Class III), can often produce side effects that outweigh their potential benefits. For this reason, doctors are usually reluctant to prescribe them unless the arrhythmia being treated is very disruptive to a patient's life — … Antiarrhythmic Drugs: ebook jetzt bei Weltbild.de als Download
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1 Jan 2015 ... While many advances have occurred in the nonpharmacologic treatment of ventricular arrhythmias, antiarrhythmic medications remain ...
Antiarrhythmic - definition of antiarrhythmic by … Define antiarrhythmic. antiarrhythmic synonyms, antiarrhythmic pronunciation, antiarrhythmic translation, English dictionary definition of antiarrhythmic. adj. Preventing or alleviating irregularities in the force or rhythm of the heart. n. An antiarrhythmic drug. n a drug that corrects irregular heartbeat adj
03.04.2010 · Inadequacies in current therapies for atrial fibrillation have made new drug development crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia. In drug development, the focus has been on favourable multichannel-blocking profiles, atrial-specific ion-channels, and novel non-channel targets (upstream therapy).
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Antiarrhythmic drugs do not lend themselves to a neat classification scheme. Many of these drugs have effects on multiple ion channels and adrenergic receptors as well as a myriad of cardiac and noncardiovascular side effects. The majority of available antiarrhythmic drugs exert predominant effects on cardiac sodium or potassium currents.