Purinergic Receptors.pdf

Purinergic Receptors

Fifty-odd years have elapsed since the first observation of the response of visceral smooth muscle to an adenine nucleotide was reported by Drury and Szent Gyorgi (1929). It is now known that purinergic receptors mediating responses to adenosine and the adenine nucleotides (AMP, ADP and ATP) are present in all types of visceral smooth muscle. Adenine itself and other endogenous purine derivatives appear to have no direct effects, or only minimal effects, on most visceral smooth muscles. Airway smooth muscle is an exception in this regard, and responds to purine bases and non-adenine nucleosides and nucleotides. Knowledge of the distribution of purinergic receptor sites on the plasma membrane of visceral musculature has grown particularly rapidly since Burnstock and his colleagues (1970) proposed that ATP, or a related adenine derivative, is the inhibitory transmitter released from non­ cholinergic non-adrenergic nerves present in the gut. Much evidence has been presented favoring the view that ATP is the inhibitory transmitter, and evidence to the contrary has also been put forward. The hypothesis remains controversial primarily because specific blockers of the postsynaptic purinergic site, with which the hypothesis might be tested, have not been found. Nevertheless, the numerous studies designed to investigate the purinergic nerve hypothesis have generated much information concerning the nature of the purinergic receptors in visceral smooth muscle.

The P1 receptor group is subcategorised into the A 1 A 2A A 2B and A 3 receptors and the P2 receptor group into the P2X subcategory, (composed of the P2X 1-7 receptors) and the P2Y subcategory (composed of P2Y 1, 2, 4, 6, 11-14 receptors). See diagram below. The purinergic receptor …

9.68 MB DATEIGRÖSSE
9400958188 ISBN
Englisch SPRACHE
Purinergic Receptors.pdf

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Sofia Voigt

Lernen Sie die Übersetzung für 'receptor' in LEOs Englisch ⇔ Deutsch Wörterbuch. Mit Flexionstabellen der verschiedenen Fälle und Zeiten Aussprache und relevante Diskussionen Kostenloser Vokabeltrainer purinergic receptors - Deutsch-Übersetzung – Linguee ...

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Noel Schulze

1 Feb 2008 ... Thus, ATP acting at multiple purinergic receptors, either directly on neurons (e.g., P2X3, P2X2/3, and P2Y receptors) or indirectly through ...

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Jason Lehmann

1 Feb 2008 ... Thus, ATP acting at multiple purinergic receptors, either directly on neurons (e.g., P2X3, P2X2/3, and P2Y receptors) or indirectly through ... 1 May 2017 ... Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells. Wayne Stallaert, Emma ...

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Jessica Kohmann

Purinergic Receptors. Purinergic receptors bind to ATP or other nucleotide analogs and to its breakdown product adenosine. Although ATP is a common constituent found within synaptic vesicles, adenosine is not and is therefore not considered a “classic” neurotransmitter. However, the multitude of receptors that are activated by adenosine