Structural and Functional Characterization of the Immunoproteasome.pdf

Structural and Functional Characterization of the Immunoproteasome

Eva Maria Huber

In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.

Structural and Functional Characterization of the … 18.01.2008 · Structural and Functional Characterization of the TRI101 Trichothecene 3-O-Acetyltransferase from Fusarium sporotrichioides and Fusarium graminearumKINETIC INSIGHTS TO COMBATING FUSARIUM HEAD BLIGHT *

1.69 MB DATEIGRÖSSE
3319015559 ISBN
Englisch SPRACHE
Structural and Functional Characterization of the Immunoproteasome.pdf

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