Single Agents in Cancer Chemotherapy
R. B. LivingstonThe clinical trials program of anti-tumor drugs was started by the National Cancer Institute in 1955. In the past 15 years, this national network has collected a large body of data on all of the recognized anti-tumor drugs as well as upon new, experimentally promising agents. While the most important of these studies have been published, there has remained a wealth of data not generally available to the scientific community. Drs. Carter and Livingston have not only succeeded in organ~z~ng this large corpus, they have in addition analyzed and interpreted the clinical data in a way that will be highly useful for years to come. From a perusal of this volume it becomes apparent that some drugs are more active against certain tumors than had been realized
Drug resistance remains a major cause of treatment failure in cancer ... Entrapment and degradation of drugs within endolysosomes is one of the key challenges ...
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