Mass Spectrometry in Drug Metabolism and Pharmacokinetics
This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.
Find liquid chromatography coupled with mass spectrometry (LC/MS) for screening, identification, and quantitation of drug metabolites in biological matrices. Select candidates with desirable drug metabolism and pharmacokinetic profiles. ... as reactive metabolite screening using state-of-the-art Mass Spectrometry ...
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This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics.
Mass Spectrometry and Chromatography (PHSC-845: Quantitative Pharmaceutical Sciences) (2008-present). • Pharmacokinetics and Drug Metabolism ... 1 May 2017 ... Quantification of metabolites by mass spectrometry in the absence of authentic ... A set of 71 clinically relevant drugs/metabolites encompassing ... is thus vital to assessments of pharmacokinetics, efficacy, toxicokinetics, and toxicity. ... as " metabolic stability," the potential benefits of metabolite quantification ...