Excitatory Amino Acid Transmission in Health and Disease.pdf

Excitatory Amino Acid Transmission in Health and Disease

Robert Balazs

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). It regulates normal CNS function, is a major participant in pathology, and serves learning, memory, and higher cognitive functions. The 12 chapters of this book provide the first comprehensive coverage of all the major features of glutamate as excitatory neurotransmitter. The book begins with a valuable historical backdrop. Building from a chapter on the common structure of glutamate receptors, several others cover the major ionotropic receptors, their structure, function, and pharmacology. A follow-up chapter discusses the metabotropic receptors that are directly coupled to second messenger metabolism. A central theme of the book is the capacity of the excitatory amino acid system to contribute to the diverse array of signaling systems in the CNS as a direct result of the large assortment of receptors (including, for the ionotropic receptors, various subunits) the combination of which determine distinct functional properties. A recent development in the field discussed in several chapters is the biochemical characterization of a supermolecular protein complex, the post-synaptic density, that makes the unique structure of excitatory synapses. This complex subserves the experience-dependent modulation of synaptic strength and synaptic plasticity, and gives the synapse the capacity to change dynamically in both structure and receptor composition. Drawing on the individual properties of the receptors, transporters, and functional architecture of the synapse, the concluding chapters describe the functional integration of these components in the more complex physiological processes of plasticity and pathology. Recognition that the regulation of excitatory amino acid receptor activity underlies the pathology of many neurological diseases, including stroke, Alzheimers disease and schizophrenia, has opened up an exciting frontier that will allow the translation of our understanding of these basic mechanisms into new concepts of pathology and new therapeutic strategies. This book will be invaluable for neuroscientists, pharmacologists, neurologists, and psychiatrists, and for their students and trainees.

SLC1A3 - Excitatory amino acid transporter 1 - … Functions as a symporter that transports one amino acid molecule together with two or three Na + ions and one proton, in parallel with the counter-transport of one K + ion (PubMed:20477940). Mediates Cl-flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na + symport (PubMed

1.93 MB DATEIGRÖSSE
0198034172 ISBN
Englisch SPRACHE
Excitatory Amino Acid Transmission in Health and Disease.pdf

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Sofia Voigt

This neurotransmitter is an excitatory amino acid and plays an important part in regards to memory. If glutamate levels are too high, major neurotoxic effects will be noted. Glutamate is toxic to neurons at elevated levels and its excess will kill the helpful nerve cells. This chemical has been implicated in the brain damage caused by the

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Matteo Müller

Disease description A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior).

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Noel Schulze

Excitatory Amino Acid Transmission in Health and Disease - Robert Balazs - 楽天Koboなら漫画、小説、ビジネス書、ラノベなど電子書籍がスマホ、タブレット、パソコン用無料アプリで今すぐ読める。

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Jason Lehmann

Abstract. Excitatory amino acids play a crucial role in the initiation and spread of epileptic activity (1). They are also excitotoxins that can cause selective neuropathology when present in concentrations moderately or substantially exceeding those normally found in the synaptic space. Excitatory Amino Acid Transporter 2 - an overview ...

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Jessica Kohmann

Excitatory amino acid transmission in health and disease (2006) Amino acid neurotransmission (1998) Excitatory amino acid receptors (1992) Neurotoxicity of excitatory amino acids (1990) Auteurs en relation avec ce thème (3 ressources dans data.bnf.fr) Auteur du texte (3) Glutamate Transporters in Neurologic Disease | …