Cancer Immunotherapy at the Crossroads.pdf

Cancer Immunotherapy at the Crossroads

Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human tumors, focusing on tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), that may serve as biomarkers for patient prognosis. They discuss the means by which these immune functions may be protected or restored in order to more effectively support the process of tumor rejection in situ. Cutting-edge techniques are outlined with the capacity to monitor the strength and quality of patients immune responses using immunocytometry, MHC-peptide tetramers combined with apoptosis assay, ELISPOT assay, and detection of MHC-TAA peptide complexes on tumor cells.

Immunotherapy is a type of cancer treatment that helps your immune system fight cancer. The immune system helps your body fight infections and other diseases. It is made up of white blood cells and organs and tissues of the lymph system.. Immunotherapy is a type of biological therapy.Biological therapy is a type of treatment that uses substances made from living …

1468498444 ISBN
Englisch SPRACHE
Cancer Immunotherapy at the Crossroads.pdf


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Alvaro Teijeira, Saray Garasa, Inaki Etxeberria, Maria Gato-Cañas, Ignacio Melero, Greg M. Delgoffe. Cancer Immunology Research Oct 2019, 7 (10) 1564- 1569 ... We are indeed at a crossroads in cancer immunotherapy—tumor immunology has progressed to a point at which it is widely accepted that antitumor immune ...

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